海〓姙娠時ニ於ケル〓ゐたみんC缺乏食飼養ガ母兒ニ及ボス影響

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概要

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• Pregnant guinea-pigs were fed on various kinds of Vitamin C-deficient foods specially chosen by the writer, such as bean-curd refuse combined with salted or boiled vegetables, egg-yolk or milk; American flour with salted vegetables; white rice flour with dry milk; or whole rice flour with dry milk, and the clinical process was observed. The changes in the blood, the growth of the teeth, and the post mortem condition were examined. It was proved that these findings were not the results of starvation, and the morbid change thus caused was found to disappear when Vitamin C was added to the diets mentioned. It was confirmed that the diets chosen caused the typical Vitamin C-deficiency disease, and that even in non-pregnant guinea-pigs the Vitamin C-deficiency disease can be caused by the diets mentioned. From the results obtained the differences between pregnant and non-pregnant guinea-pigs were investigated and the following conclusions reached. 1) When pregnant guinea-pigs were fed on the diet chosen by the writer for the purpose, the Vitamin C-deficiency disease was caused in the maternal body, as well as in non-pregnant animals. In the pregnant guinea-pigs, interruption of pregnancy was caused in almost all cases, the process of labour was markedly retarded, and parturition rendered difficult. 2) The process of the Vitamin C-deficiency disease and the findings in pregnant guinea-pigs resemble on the whole those of the non-pregnant. The principal differences are as follows: a) The appearance of the Vitamin C-deficiency disease is delayed in pregnant guinea-pigs as compared with the non-pregnant. b) Once the pregnant guinea-pig contracts the Vitamin C-deficiency disease, the symptoms become rapidly worse and the animal dies more rapidly than the non-pregnant. c) The average daily rate of the decrease in weight due to the Vitamin C-deficiency disease during the period of affection is much greater (about twice) in pregnant than in non-pregnant guinea-pigs. d) In both pregnant and non-pregnant guinea-pigs a decrease in the number of erythrocytes and in the hemoglobin content, and a rapid increase in the reticulocytes (substantia reticulo-filamentosa) and in basophilic granular erythrocytes were produced. But in pregnant guinea-pigs, the change was more marked, with rapid aggravation as labour progressed. e) The rate of growth of the teeth was irregular both in the pregnant and in the non-pregnant guinea-pigs; rapid growth and retardation succeeded each other, but in the pregnant animals the fluctuation was generally more marked, and appeared at an earlier stage. f) As for other autopsical findings in general, the degree of morbid change was far more serious in pregnant guinea-pigs than in the non-pregnant. In short, the morbid change in pregnant guinea-pigs due to Vitamin C-deficiency is more serious than in the non-pregnant. The general condition, the findings in the blood, the condition of the teeth and the autopsy findings in fetuses and young animals obtained from such mother-animals as described above, were also observed and at the same time X ray examinations were made and the following results were obtained: The fetuses and young animals obtained from mother animald fed on the Vitamin C-deficient diet had already been influenced in the womb by the disease, and as a result the morbid change peculiar to the disease had been produced in them. Moreover the effect was proportional to the number of days the maternal animal had been fed on the Vitamin C-deficient diet.

• 京都府立医科大学の論文

著者

• 藤野 幸太郎

  京都府立醫科大學

関連論文

• 海〓姙娠時ニ於ケル〓ゐたみんC缺乏食飼養ガ母兒ニ及ボス影響(學位論文審査要旨)
• 海〓姙娠時ニ於ケル〓ゐたみんC缺乏食飼養ガ母兒ニ及ボス影響
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