尿浸潤ニ關スル實驗的研究 : 總序 第一編 病理組織學的研究
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The methods adopted by the authors to produce an experimental urine-infiltration were as follows: (1) Twenty cubic centimetres of urine obtained from each of ten healthy male rabbits of nearly the same weight was injected subcutaneously in the scroto-perineal region of the rabbits, each rabbit having its own urine injected. In some of them the obervations were carried out after one injection. Most of them, however, received injections on successive days till they were exhausted or even died off, the former being killed by means of venesection or with a blow. (2) The urine was first put into an incubator at 37℃. for a few days. After that it was injected into five rabbits under the same conditions and in the same manner as in (1). (3) The mucous membrane of the urethra of five rabbits in the same condition as the above was cut variously with the point of a tiny scalpel at several parts so as to make the urine-infiltration as natural as possible. (4) As controle, twenty cubic centimetres of physiological salt solution was injected into five rabbits in the same condition as stated in (1). Through the observation of the lesion caused by the injection and the necropsy of the animals, the following facts were proved. A) The skin of the injected part shows inflammatory oedema of high degree and the scrotum could be swollen to the size of a hen's egg on the second day. The swelling would reduce more or less, as a rule, on the third bay. On the following days induration took place at the periphery of the lesion, which increased in its extent more and more, while the centeral part broked through spontaneously with secretion of serous matter, a pre-stadium of ulceration. It did not take long before the latter got necrosed and formed a real ulcer. It might, of course, be infected subsequently and a dirty necrotic tissue with sanious pus matter would often be noticed. If the injections were not continued granulationtissus would take the place of the ulcer and cicatrical healing would occur, but if it happened that the injections were continued, the lesion incresed and the animals got reduced, having poor appetite and at last they died. B) There wos no marked difference between (1) and (2). C) It seemed very difficult to cause urine-infiltration by method (3), as the inflammatory oedeme of the lesion was usually absorbed within a few days except one, which proved no tendency to absorption, but a changing of the tint of the lesion into dark red violet and on the fourth day from the beginning it nearly died. D) Although the testicle as well as the epididymis were often exposed through the necrosis of the scrotum to the outside, neither their parenchyma nor the peritoneum was affected. E) The macroscopical change of the internal organs was passive hyperaemia, which was most marked in the liver and kidney. F) The microscopical findings of the internal organs consisted in passive hyperaemia of the liver, spleen and kidney, and cloudy swelling in some part of the heart, liver and kidney. G) These changes of experimental urine-infiltration stated above resembled very much those of septicaemia and uremia, but the authors mainted maintain that there is some difference between the two in their origin.
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