P-23 タンザニア原産植物Strychnos cocculoidesから単離した新規二量体イリドイド配糖体(ポスター発表の部)

概要

論文の詳細を見る
Strychnos cocculoides is a widely distributed plant in tropical regions. Its root barks are locally used in Tanzania folk medicine for the treatment of snake bites, fever and stomach pain. Strychnos species are reputed to their wide distribution of compounds such as trimeric indolomonoterpenic alkaloids (Phillippe et al., 2003). The present studies were carried out on methanolic extracts from stem and roots of Strychnos cocculoides. We have isolated the new bis-iridoid glucoside, composed of two known compounds 3 and 4, and named Cocculoside (1). We also isolated some known compounds, a phenolic glucoside, 2-Hydroxy-3-O-β-D-glucopyranosyl-benzoic acid (2) (Rashid et al., 1996), together with iridoid glucosides, Loganic acid (5) (Zhang et al., 2003), Morroniside (6) (Otsuka et al., 2001), and a iridoid monoterpene, Sarracenin (7) (Miles et al., 1976). Compound 6 was isolated as a major component and observed in the ^1H NMR spectrum as a mixture of the anomeric forms. Morronoside (6) and Sarracenin (7) have been isolated from plant of the genus Strychnos for the first time.
2008-09-01