Brownian Dynamics Simulations of a Wild Type and Mutants of Bovine Pancreatic Trypsin Inhibitors(Biochemistry)
スポンサーリンク
概要
- 論文の詳細を見る
Brownian dynamics simulations of a wild type and mutants of bovine pancreatic trypsin inhibitors were performed using the program brownian. The results of the simulations were consistent with experimentally determined stabilities of these proteins, and the computational times of the simulations were much less than those of molecular dynamics simulations. These results indicate that Brownian dynamics simulations can be useful for investigating structural features of proteins that have some mutants, such as drug-metabolizing enzymes.
- 公益社団法人日本薬学会の論文
- 2008-12-01
著者
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Oda Akifumi
Faculty of Pharm Sci, Tohoku Pharm Univ
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Takahashi Ohgi
Faculty of Pharm Sci, Tohoku Pharm Univ
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Takahashi Ohgi
Faculty Of Pharm Sci Tohoku Pharm Univ
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Oda Akifumi
Faculty Of Pharm Sci Tohoku Pharm Univ:institute For Protein Research Osaka Univ
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Oda Akifumi
Discovery Laboratories Toyama Chemical Co. Ltd.
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Hirono Shuichi
Laboratory Of Physical Chemistry For Drug Design School Of Pharmaceutical Sciences Kitasato Universi
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Hirono Shuichi
School Of Pharmaceutical Sciences Kitasato University
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YAMAOTSU Noriyuki
School of Pharmaceutical Sciences, Kitasato University
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Yamaotsu Noriyuki
Laboratory Of Physical Chemistry For Drug Design School Of Pharmaceutical Sciences Kitasato Universi
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Yamaotsu Noriyuki
School Of Pharmaceutical Sciences Kitasato University
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TAKAHASHI Ohgi
Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University
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