Fast Repair Activities Towards dGMP Hydroxyl Radical Adducts by Silybin and its Analogues

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概要

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• The repair activities of silybin (SLB) and its analogues towards the oxidizing deoxyguanosine monophosphate (dGMP) hydroxyl radical adducts are investigated by pulse radiolytic techniques. On pulse irradiation of nitrous oxide saturated 2.0mM dGMP aqueous solution containing 0.1mM silybin at neutral pH, the transient absorption spectrum of the dGMP hydroxyl radical adducts decreases with the formation of the phenoxyl radical of silybin within tens of microseconds, indicating that there is a repair reaction between the dGMP hydroxyl radical adduct and silybin. The rate constant of the repair reaction is calculated to be 1.0×10^9M^<-1>s^<-1> for silybin. The repair activity of hesperetin (HESP), naringin (NAN) and naringenin (NAR) towards hydroxyl radical adducts of dGMP are also studied.

• 2008-11-16

著者

• Yoshioka Katsuji

  Nuclear Engineering Research Laboratory Graduate School Of Engineering The University Of Tokyo

• FU Haiying

  Nuclear Professional School, School of Engineering, The University of Tokyo

• KATSUMURA Yosuke

  Advanced Science Research Center, Japan Atomic Energy Agency

• LIN Mingzhang

  Advanced Science Research Center, Japan Atomic Energy Agency

• HATA Kuniki

  Nuclear Professional School, School of Engineering, The University of Tokyo

• MUROYA Yusa

  Nuclear Professional School, School of Engineering, The University of Tokyo

• HATANO Yoshihiko

  Advanced Science Research Center, Japan Atomic Energy Agency

• Fu Haiying

  Nuclear Professional School School Of Engineering The University Of Tokyo

• Hatano Yoshihiko

  Advanced Science Research Center Japan Atomic Energy Agency

• Muroya Yusa

  Nuclear Engineering Research Laboratory Graduated School Of Engineering University Of Tokyo

• Hata Kuniki

  Department Of Nuclear Engineering And Management School Of Engineering The University Of Tokyo

• Lin Mingzhang

  Nuclear Science And Engineering Directorate Japan Atomic Energy Agency

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