UNDERSTANDING OF DISTRIBUTION FEATURES OF SYSTOLIC BLOOD PRESSURE USING FREQUENCY DISTRIBUTION ANALYSIS

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In general, it is considered that blood pressure measurements appear to fit well with a normal distribution. Blood pressure distribution obtained by epidemiological study, however, can always not be approximated by normal distribution well. Deviations from a normal distribution are often shown. In the current study, frequency distribution analysis was used to examine the distribution features of systolic blood pressure and its change by age. We examined the systolic blood pressure obtained on regular checkups of 4249 male post office workers, aged 40-57 years. In our population, the blood pressure frequency distributions have tails stretching out further on the side where the blood pressure is high, and thus have deviation from the normal distribution. In attempt to improve the goodness of fit, a probabilistic model of blood pressure was created on the basis of the possible existence of a subpopulation on the side where the blood pressure is high. Two theoretical, discrete populations of blood pressure were identified. Recent studies have described that a natural real threshold, which depends on sex and age, exists for systolic blood pressure that is related to cardiovascular death. In our model, the expected value for the subpopulation distribution at a given age, located on the side where blood pressure was high, corresponded well with this natural cut-off value for hypertension, which depends on age. These findings suggest that systolic blood pressure distribution may be composed of two subpopulations, and moreover, hypertensives and normotensives can be identified according to the distribution features of systolic blood pressure at a given age.
名古屋市立大学の論文

UNDERSTANDING OF DISTRIBUTION FEATURES OF SYSTOLIC BLOOD PRESSURE USING FREQUENCY DISTRIBUTION ANALYSIS

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