Vitamin E Supplementation Attenuates Strenuous Exercise Induced DNA Damage and Lipid Peroxidation of the Liver in Rats

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This study was designed to investigate the effects of vitamin E supplementation on exercise-induced DNA damage and lipid peroxidation in rat livers. Male Wistar rats were divided into three groups: a sedentary control (CON) group fed a control diet, and two exercise groups, one fed a control diet (EX) and the other fed a vitamin E supplemented diet (EX+VE). The exercise groups performed treadmill runs for 4 weeks, 5 days a week for 30 minutes per day. Thiobarbituric acid reactive substance (TBARS) levels in the EX+VE group were significantly lower than the EX group (p<0.05). Hepatic 8 - hydroxydeoxyguanosine (OHdG) in the EX+VE group was also significantly lower than the EX group (p<0.05). The results showed that there was oxidative damage to lipids and DNA due to exhausting exercise together with a decrease in α-tocopherol levels in the liver due to lipid peroxidation. However, when high levels of vitamin E were added to the diet, TBARS levels in the liver significantly decreased and the increase in hepatic 8-OHdG levels was suppressed. These results suggest that intake of antioxidants plays an important role in protection against oxidative stress of the liver when performing strenuous exercise.
川崎医療福祉大学の論文