Purification and Determination of the Chemical Structure of the Tyrosinase Inhibitor Produced by Trichoderma viride Strain H1-7 from a Marine Environment(Microbiology)
スポンサーリンク
概要
- 論文の詳細を見る
Tyrosinase is a key enzyme in the synthesis of melanin and is widely distributed in animals, plants, and microorganisms. As excessive melanin production causes not only hyperpigmenting effects on human skin but also melanosis in various foods, an inhibitor of tyrosinase has become of interest lately from a practical point of view. In the present study, we purified the tyrosinase inhibitor produced by Trichoderma viride strain H1-7 from a marine environment. The purified inhibitor showed a single peak on HPLC. The chemical structure of this com-pound was determined by NMR and mass spectrometry analyses. The structure was the same as homothallin II that has been isolated as an antibiotic from T. koningii and T. harzianum. The inhibitor showed competitive inhibition against mushroom tyrosinase.
- 2008-08-01
著者
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Kobayashi T
School Of Bioscience And Biotechnology Chubu University
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TSUCHIYA Takahiro
Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine
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Kobayashi T
Graduate School Of Marine Science And Technology Tokyo University Of Marine Science And Technology
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KOBAYASHI Takeshi
Graduate School of Engineering Science, Osaka University
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MIYAMOTO Katsushiro
Department of Microbiology, Osaka University of Pharmaceutical Sciences
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TSUJIBO Hiroshi
Department of Microbiology, Osaka University of Pharmaceutical Sciences
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Imada Chiaki
Graduate School Of Marine Science And Technology Tokyo University Of Marine Science And Technology
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YAMADA KATSUHISA
Tokyo University of Marine Science and Technology
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Tsuchiya Takahiro
Department Of Microbiology Osaka University Of Pharmaceutical Sciences
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Tsuchiya Takahiro
Department Of Chemistry Tokyo Gakugei University
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Imada C
Graduate School Of Marine Science And Technology Tokyo University Of Marine Science And Technology
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Usami Yoshihide
Department Of Organic Chemistry Osaka University Of Pharmaceutical Sciences
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Tsujibo H
Department Of Microbiology Osaka University Of Pharmaceutical Sciences
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Hamada-sato Naoko
Graduate School Of Marine Science And Technology Tokyo University Of Marine Science And Technology
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YAMADA Katsuhisa
Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology
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MINOURA Katsuhiko
Central Research Laboratories, Osaka University of Pharmaceutical Sciences
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Miyamoto K
Central Research Laboratories Osaka University Of Pharmaceutical Sciences
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Kobayashi T
Graduate School Of Engineering Science Osaka University
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