マイクロ・ナノチップテクノロジーを利用した機能的タンパク質解析デバイスの創成に関する研究
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概要
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Given the trajectory of interest and innovation in this marriage of micro and nano-chip technology and proteomics, it is speculated that micro and nano-chip technology for proteomics are indeed on the horizon. Thus, further investigations on functional protein analysis devices by micro and nanochip technology are still needed to make this a success. This study focused on improving signal-tonoise (S/N) ratio so as to efficiently manipulate proteins in micro and nano-chips to realize high-performance analysis. In detail, this study is mainly composed of 4 topics : suppression of protein adsorption on channel walls of a poly(methyl methacrylate) (PMMA) microchip (in chapter 2); high performance protein separation with cellulose derivatives (in chapter 3); a sieving matrix for microchip electrophoresis of protein (in chapter 4); and development of a highly sensitive protein detection method on microchip electrophoresis and analysis of milk protein (in chapter 5). In addition, a general introduction was added in chapter 1 and concluding remarks and future perspectives are presented in chapter 6. Namely, this thesis is composed of 6 chapters.
- 2008-07-05