Polymorphism of NQO1 (C609T) in Relation to Susceptibility to Oral Squamous Cell Carcinoma

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概要

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• The NQO1 gene, encoding the phase II drug-metabolizing enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1), is regarded as an important enzyme for susceptibility to carcinogenesis in humans. Japanese people show a polymorphism (C609T) in NQO1 as C in the wild-type genotype (wt) and T in the variant genotype (vt). In this study of 105 patients with oral squamous cell carcinoma (OSCC), the wt/wt, wt/vt and vt/vt genotypes were found in 42, 49 and 14 cases, respectively, while each genotype was detected in 49, 52 and 1, respectively, of 102 control cases with no carcinoma at any site in the body. The X^2 test revealed that individuals with the vt/vt genotype were less common in the control cases than in the OSCC patients (P < 0.001) and the odds ratio of the vt/vt to the wt/wt genotype was 16.3. The results indicate that susceptibility to OSCC appears to depend significantly on the NQO1 polymorphism.

• 特定非営利活動法人日本臨床口腔病理学会の論文
• 2003-06-25

著者

• HIRANO Masato

  Department of Oral Pathology, Kagoshima University Dental School

• Hirano Masato

  Department Of Oral Pathology Kagoshima University Dental School

関連論文

• Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers
• Five Quantitative Trait Loci Affecting 4-Nitroquinoline 1-Oxide-induced Tongue Cancer in the Rat
• Polymorphism of NQO1 (C609T) in Relation to Susceptibility to Oral Squamous Cell Carcinoma

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