P-28 コウゾ(Broussonetia kazinoki Sieb.)から得られる新ピロリジンアルカロイドおよび配糖体の構造(ポスター発表の部)

概要

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In the course of searching alkaloids having inhibitory activities to glycosidases from medicinal plants, we isolated new five pyrrolidine alkaloids (1-5) from Broussonetia kazinoki Sieb. (Moraceae). Compounds (1-5) were obtained by repeated chromatographies of hot water extracts on Amberlite CG-50 and Diaion HP-20, followed by HPLC, and their structure were investigated by chemical and spectral methods. Compounds 1 and 2 were clarified to be 4-O-β-D-glucopyranoside of aglycone(1a and 2a ), and 1a was formulated as 2β -hydroxymethyl-3β,4β-dihydroxy-5 α-(10'keto-13'-hydroxy-tridecyl)-pyrrolidine, while 2a was 2β-hydroxymethyl-3β,4β-dihydroxy-5α-(9'keto-13'-hydroxy-tridecyl)-pyrrolidine. Similarly, 3 was formulated as 2β-hydroxymethyl-3α,4β-dihydroxy-5α-(9'keto-13'-hydroxy-tridecyl)-pyrrolidine, while 4 was 2β-hydroxymethyl-3α,4β-dihydroxy-5α-(10'keto-13'-hydroxy-tridecyl)-pyrrolidine. 5 was supposed to be a related pyrrolidine compound with addition of one mol. of water.
天然有機化合物討論会の論文
1995-09-01