有機酸並に其塩類の循環器系統に及ぼす影響に就て : 第五報 酒石酸の影響

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概要

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• The author injected intravenously the aqueous solution of tartaric acid of various concentrations each 0.5 cc per Kg, into rabbits and observed their effect on the circulatory system. Immediately after the injection of 10 % solution, the maximal blood pressure showed an average decrease of 5.7 %, the minimal blood pressure showed an average decrease of 10.1 % and the pulse curve amplitude decreased on the average 18.7 %. All these conditions returned to normal gradually. By the injection of 7.5 % solution, the pulse curve amplitude decreased in some measure and the pulse rate showed a slight increase immediately, but the blood pressure was almost unchanged. By the injection of 3.75 % solution, the maximal blood pressure increased on the average 6.4 % in 5〜15 minutes after the injection, the minimal Blood pressure showed a tendency towards an increase and the pulse, rate, increased in some degree immediately after the injection. Comparing the effect of tartaric acid upon the circulatory system above described with those of acetic acid and lactic acid on which the author has previously reported, we note the following : on the injection of 5/3 normal solution each of these acids similarly decreases the blood pressure and they differ only in the extent of this effect; on the injection of 1 normal solution tartaric acid has no effect on the blood pressure while acetic acid or lactic acid decreases the blood pressure ; and on the injection of 1/2 normal solution, in contrast to acetic acid and lactic acid which have no effect on the blood pressure, tartaric acid increases the blood pressure though in only a slight degree. I am much indebted to Prof. Toshikazu Mashimo, M. D. and Assist. Prof. Magoziro Maekaawa, M. D. for their kind guidance throughout this experiment.

• 社団法人日本循環器学会の論文
• 1939-03-01

著者

• 辻田 正典

  京都帝國大學大學院

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