コレステロール代謝に関わる核内受容体Farnesoid X Receptorの解析(誌上シンポジウム)
スポンサーリンク
概要
- 論文の詳細を見る
Nuclear receptors function as ligand-inducible transcription factors that regulate various physiological functions such as development, reproduction, and metabolism. Dysregulation of the metabolism of cholesterol, triglyceride, and glucose leads to the metabolic syndrome including type 2 diabetes mellitus, obesity, dyslipidemia, and atherosclerosis. Studies of nuclear receptors promise to provide discoveries of therapeutic agents against the metabolic syndrome. Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and is activated by bile acids. FXR regulates the metabolism of not only bile acid but also cholesterol, lipoprotein, triglyceride, and glucose, and is considered a potential therapeutic target for the metabolic syndrome because of these functions. Nuclear receptors have two regions for transactivation, a constitutive activation function (AF-1) and a ligand-dependent activation function (AF-2). AF-1 and AF-2 seem to require interactions with coactivators for the activation function and both work synergistically to give full transactivation of nuclear receptors. However, coactivators for AF-1 activity are poorly understood, whereas coactivators required for AF-2 activity have been well studied. To understand the molecular mechanism of AF-1 in FXR, we isolated proteins associated with AF-1 by GST pull-down assay using the N-terminal region of FXR and nuclear extracts from HeLa cells. This review focuses on the roles of FXR and our new findings regarding FXR-associated factors.
- 2008-03-01
著者
関連論文
- コレステロール代謝に関わる核内受容体Farnesoid X Receptorの解析(誌上シンポジウム)
- OP-281 Vardenafil連日投与の効果は投与中止後も持続するのか? : 動脈性EDラットによる検討(不妊・Andrology2,一般演題口演,第99回日本泌尿器科学会総会)
- P1-236 シスプラチン誘発性腎障害に対する新規診断マーカーとしての尿中ADMAの検討(がん薬物療法(他の副作用対策),ポスター,一般演題,岐路に立つ医療〜千年紀の目覚め〜よみがえれ!ニッポン!薬の改革は我らが手で!)