緑色連鎖状球菌に依る實驗的心炎の研究(第1報)

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Maekawa expresses the opinion that in the allergic diseases phosphatide from any organ or tissue makes the antigen combine with that organ or tissue. Therefore, I expected that when rabbits were sensitized by the mixture of streptococci viridans and rabbit-heart-muscle or men-heart-endcardium-phosphatide, the cocci would adhere to the heart to produce an allergic carditis. On the first experiment I sensitized rabbits by the intertesticular injection of the streptococci viridans with rabbit-hert-muscle-phosphatide. Clinically body weight, body temperature, blood pressure, blood picture and urines were not so changed, but electrocardiogram showed myocardial damages CPR-reaction by Araki showed positive and complement in the blood decreased. After killing the rabbits, I investigated histologically all organs of them, especially heart. I found more remarkable allergic interstitial myocarditis at the experimental rabbits I found a large basophilic monnuclear cell in the perivascular plasma cells. The purulence and incease of the connective tissure were recognized in the testicles of all animals.
社団法人日本循環器学会の論文
1953-12-20