ニコチンと心筋ホスファチードとの向心筋作用の相關性に關する研究
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概要
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It was suggested by Prof. Maekawa for the first time that the organ specifity of an allergic reation was brought forth as the result of the participation in the allergic reaction of the substances showing special affinity to the organ involved. This has been proved experimentally by Prof. Maekawa's students, who used digitalis, nicotine and the phosphatide of the heart muscle as "cardio-tropic" substances are identical in their effect on the heart muscle. Two groups of rabbits were used to inquire after the "cardiotropic" action of nicotine and cardiac phosphatide. Group A was injected with the mixture of nicotine and ox serum for four days as the sensitization procedure and after three weeks the mixture of cardiac phosphatide and ox serum are injected for three days. Group B was treated similarly, but the sensitizing process was arranged contary to the case of group A. Body weight blood pressure, Arthus phenomenon, electrocardiogram and histological change were studied. The most important findings were obtained in the electrocardiographic and histological examination. As electrocardiographical findings we were able to point out tachycardia, lower T waves and ST transportation. As histological findings periarteritis were often seen in the myocardium of every rabbit. Cell infiltrations showed the speciality of the allergic change such as plasma cells, histiocytes, connective tissue cells and pseudo-eosinophile cells. Other organs showed no remarkable allergic changes. The experiment established similar effect of two "cardiotrope: substances in spite of their chemically very different structures. Nicotine, one kind of alkaloids, has a chamical nature like a base. Proteins which have amino and carboxyl bases combine with alkaline substances and produce some compounds like bases. So it is with a high probability that nicotine combines with protein. On the other hand lipoidprotein combinations are well known as lipoproteins. This expriment suggests that both nicotine and phosphatide of cardiac muscle bring the allergic reaction to the heart muscle in spite of their very different chemical structures.
- 社団法人日本循環器学会の論文
- 1953-11-20
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