腎炎に關する實驗的研究(第1報) : 腎臓ホスファティードに依る實驗的高血壓症(1)

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From the old time many studies on hypertension had been done, and Goldblatt succeed for the first time experimentally to establish a persistent hypertension, which would be due to renal ischemia. On the other hand hypertension is one of the cardinal signs of the diffuse glomerulonephritis. And Masugi proved that the diffuse glomerulonephritis has its origin in allergic changes due to a antigen-antibody reaction. Maekawa thought that, if we wish to establish an allergic inflammation in any tissue or organ, we must make the antigen have affinity to that tissue or organ, and that the substance gives such affinity is cell-phosphatide. Therefore, I sensitized the rabbits with a mixture of rabbit-kidney-phospatide and fresh oxen sera, and examined clinically and histologically each organ.
社団法人日本循環器学会の論文
1949-04-20