Estrogen receptors in diseases of the immune system

概要

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Estrogen has distinct functions in the immune system where it acts via ERα and HERβ respectively.Surprisingly, the defects in the immune system which develop in the absence of either ERα or ERβ are quitedistinct from what develops in the absence of estrogen. We have found by studying mice in which either or bothestrogen receptors have been inactivated that the two estrogen receptors play distinct roles in the immune system.Loss of ERβ leads to chronic myeloid leukemia and loss of ERα leads to autoimmune disease. In mice which cannotsynthesize estrogen there is also autoimmune disease resembling Sjögren’s Syndrome. We plan to study these micefurther with the aim of fi nding the exact sites of action of the two receptors in the immune system and by usingspecifi c ligands for ERα. or ERβ to examine how specifi c parts of the immune system can be modifi ed. These studiesshould lead to improved treatment of patients with diseases of the immune system.
弘前大学の論文