血液動態より見たアナフィラキシー・ショックに関する実験的研究

概要

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The anaphylactic shock was produced in the guinea pig weighing of 300 grams sensitized actively with the horse serum. They were divided into two groups, one is acute type of death within 20 minutes and the other is delayed type of death more than 20 minutes after the shock. The hemodynamics showed that the cause of the former might be asphyxia and the latter might be metabolic acidosis. All cases injected 10 mgms. of chlorpromazine survived. But the effects of buscopan, theabron or parasympathectomy were not necessarily demonstrated. The preoperative tracheotomy with an artificial respiration prolonged the of survival time. The hemodynamics also showed that O_2 in the arterial blood slightly decreased at first and came back to the normal lebel, but the concentration of CO_2 decreased continously and pH changed to acid and amino-N increased. PaCO_2, (HCO_3^-)_s and (B_B^+)_B decreased significantly and non-compensatory alkaline deficit were observed. The forced respiration right after the shocking injection and the treatment of chlorpromazine, administered 2 minutes after the provocative injection, reduced the death rate and prolonged the survival time. The result of the gas analysis (Scholander) showed that chlorpromazine have the facility of making pulmonary gas exchange easily to the guinea pig.
一般社団法人日本アレルギー学会の論文
1960-06-01