緑膿菌精製内毒素によるウサギ脳のShwartzman型病変

概要

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The article is to report a successful production of the Shwartzman phenomenon in the rabbit brain in high percentage by means of an improved method of the treatment. By using the sesame oil containing 1 per cent of endotoxin and 1.5 per cent of span 60 (surface active agent), brain was prepared to be effective sufficiently by two successive injections (each containing 2mg of toxin in 0.1ml of sesame oil) into cisterna cerebello-medularis of the material, followed by a single intravenous (1mg of toxin per capita) or intracisterna eliciting injection of the endotoxin (3mg of toxin per capita) dissolved in physiological saline after 18-20 hours. Histological Histological findings such as meningitis with leucocytes infiltration and thrombus, hemorrhages, oedema, fibrinoid necrosis of small vessels in parenchym were observed.
社団法人日本アレルギー学会の論文
1960-06-01