Transient Resensitization Interrupting the Development of Carbachol-induced Desensitization in Smooth Muscle of Guinea-pig Taenia Caeci : Ca^<2+> -dependent Termination of Resensitization
スポンサーリンク
概要
- 論文の詳細を見る
It is important to clarify developmental mechanisms of desensitization because of their great significance in regulation of cellular responsiveness. We have found that carbachol-induced desensitization to carbachol develops in three successive phases in the presence of extracellular Ca^<2+> in the smooth muscle of guinea pig taenia caeci : fast desensitization within 15s, transient resensitization reaching a peak at 1 min and the subsequent re-development of desensitization to terminate resensitization for up to 30min. In contrast, in the absence of extracellular Ca^<2+>, desensitization develops without resensitization. To further clarify the roles of Ca^<2+> in the formation of the transient resensitization phase, we examined the developmental process of carbachol-induced desensitization in the absence of extracellular Ca^<2+>, following the induction of desensitization by a 15-s treatment with carbachol in the presence of extracellular Ca^<2+>. Desensitization to carbachol occurred due to pretreatment with 10^<-4>M carbachol for 15s in normal physiological solution, and continued pretreatment with carbachol in Ca^<2+>-free solution containing 0.2mM EGTA induced resensitization followed by the obscure progress of re-desensitization for up to 30min resulting in a long-lasting phase of resensitization. These results suggest that resensitization is promptly terminated by the Ca^<2+>-dependent development of subsequent desensitization for further regulation of cellular responsiveness via G_q protein-coupled Ca^<2+>-mobilizing receptors against sustained stimuli.
- 公益社団法人日本薬学会の論文
- 2007-11-01
著者
-
菱沼 滋
Department Of Pharmacodynamics Meiji Pharmaceutical University
-
菱沼 滋
明治薬大
-
菱沼 滋
明治薬科大学薬効学教室
-
齋藤 政樹
Department Of Pharmacodynamics Meiji Pharmaceutical University
関連論文
- ヒスタミンH_1受容体の細胞内移行と薬物感受性変化
- O6-008 安定狭心症に対するニコランジルと狭心症治療薬の有効性・安全性における比較に関するメタ解析(一般演題 口頭発表,薬物療法/持参薬管理/栄養管理・NST/健康食品サプリメント,医療薬学の創る未来 科学と臨床の融合)
- 29-P3-63 明治薬科大学における長期実務実習に関する一考察 : 関東地区調整機構エリア制受け入れにおける学生満足度(薬学教育,社会の期待に応える医療薬学を)
- 30P3-132 明治薬科大学における長期実務実習に向けての薬局実習必修化に関する一考察(薬学教育・生涯教育(認定),医療薬学の扉は開かれた)
- 29-P2-158 関節リウマチ患者におけるタクロリムスとブシラミンの有効性と安全性の検討(薬物治療,社会の期待に応える医療薬学を)
- 安定狭心症に対するニコランジルの短期的有効性・安全性に関するシステマティック・レビュー：β遮断薬・持続性亜硝酸薬・Ca拮抗薬との比較
- O3-02 非小細胞肺癌患者におけるゲフィチニブの抗腫瘍効果に制酸薬が与える影響(一般演題 口頭発表,薬物相互作用/有害事象・副作用,臨床から学び臨床へと還元する医療薬学)
- Histamine Develops Homologous Desensitization under Ca2+-free Conditions with Increase in Basal Tone in Smooth Muscle of Guinea Pig Taenia Caeci
- Transient Resensitization Interrupting the Development of Carbachol-induced Desensitization in Smooth Muscle of Guinea-pig Taenia Caeci : Ca^ -dependent Termination of Resensitization
- 受容体感受性
- 受容体の脱感作機構
- P-0923 入院患者における低亜鉛血症のリスク因子の検討と亜鉛製剤投与による亜鉛欠乏関連症状への影響に関する研究(一般演題 ポスター発表,栄養管理・NST,Enjoy Pharmacists' Lifestyles)