カルシウム拮抗薬の中枢作用に関する研究(1)

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To investigate the effects of calcium channel blockers on anxiety, we established the optional condition of electric stress using Vogel type water-lick conflict behavior in rats. This condition was able to measure the anxiety excluding unspecific factors such as freezing and abnormal behavior in which conflict behavior. Water-deprived rats before 24h allowed free acsess to water by licking the spout for 5 min (shock free session). On the next day (pre-test session), they were suffered electric shock every 40 licks (44V-AC, 100msec). On the last day, they performed (drug-test session) same as the pre-test schedule except for the drug treatment at 30 min before the session. Anxiolytic, diazepam 5mg/kg, dramatically antagonized water-licks inhibiting effect more than normal level. Then we observed 3 derivatives of calcium channel blockers. Verapamil (phenylalkylamines) 20mg/kg and nicardipine (1, 4-dihydropyridines) 20mg/kg induced anticonflict action. Finally, diltiazem (benzothiazepines) but had no effect by single treatment, was also observed anticonflict action by 8 days treatment. Theses findings are suggested that calcium channel blokers may have a possibility of therapeutic effects of psychotropic disorders such as anxiety.
九州女子大学・九州女子短期大学の論文