疲労困憊にいたる長時間の漸増負荷走トレーニングに対する骨応答
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The purpose of this study was to investigate the influence of exhaustive running training for 9 weeks on the adaptation of the bone mineral, and structural and mechanical properties of the tibial middiaphysial in young and adult rats. Female Wistar Imamichi strain 4-week (Young : Y) and 10-week (Adult : A) were divided into training (T) and control (C) group, respectively. The running training was conducted on a treadmill with gradual increasing speed and slope until exhaustion. Peripheral quantitative computed tomography (pQCT) was used to examine the changes in bone mineral content (BMC) and volumetric bone mineral density (vBMD) in cortical area. Dynamic stiffness and tangent δ (tanδ) were measured with a viscoelastic spectrometer, and a three-point bending test was performed with an Instron-type universal testing machine. We also cut cross-sectional sections from the mid-shaft and evaluated morphometrical properties. By strenuous exercise training, cortical mid-shaft was markedly hypertrophied and BMC increased, wherea vBMD was slightly increased in both age groups. In dynamic mechanical test, dynamic stiffness was significant decreased and loss tanδ significant increased in Y-T, whereas in A-T, both parameters were significant enhanced. In Y-T, ultimate load, ultimate deformation and stored energy were improved, while static stiffness was slightly decreased. In Adult rats, although exercise enhanced fracture load and stored energy, ultimate deformation and static stiffness did not change. These results suggest that although the exhaustive endurance training, what is relatively same intensity Young and Adult rats, produced hypertrophy of tibial cortical area in both immature and mature, immature bone change into a more compliant material, whereas mature bone is excellent in viscoelasticity and stiff.
- 2007-03-31
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