ラット血管痛モデルにおける循環器パラメーター変動のパワースペクトル解析
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We investigated the dynamics of cardiovascular system in order to search for the characteristic of vascular pain model using power spectrum analysis. The animals were anesthetized with urethane (1.3g/kg, i.p.) and arterial cannula was inserted into a bifurcation of femoral artery. The recording of heartbeats was carried out by chest bipolar lead. Systolic blood pressure went through a transducer from femoral artery and measured it invasively. In the power spectrum density (PSD) of R-R intervals, it was almost the same as that of un-stimulating state at very low frequency (VLF, <0.08Hz) and low frequency (LF, 0.08-0.3Hz) and high frequency (HF, 0.3-4.0Hz). However, the arterial capsaicin (CAP, 0.2μg) evoked the increment of total PSD values, particularly at LF and VLF, were markedly different from those of pinching. Furthermore, the increase of PSD by CAP was inhibited by morphine (5mg/kg, s.c.). These results indicate that the useful possibility to observation of the autonomic nervous system dynamics induced by vascular pain as a characteristic of this model.
- 東北薬科大学の論文
東北薬科大学 | 論文
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- 一般教育研究(3) : 第56回東北・北海道地区大学一般教育研究会
- 一般教育研究(2) : 第55回東北・北海道地区大学一般教育研究会