ラット胎子動脈管に対するジクワットの影響

概要

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Rats on day 21 of pregnancy received a subcutaneous injection of diquat (0.5, 2, 7mg/kg). The inner diameter of the ducutus arteriosus (DA) of their fetuses was measured using the whole-body freezing method 1, 3, 6 and 24 hours after injection. The 2 and 7mg/kg dose groups showed a significant constriction of the DA 3 and 6 hours after diquat treatment. The 0.5mg/kg dose group showed no significant change in the inner diameter of the DA at any point of measurement (1, 3, 6 and 24 hours after injection). These results indicate that diquat induces constriction of the fetal rat DA in a dose-dependent manner when administered in late stages of gestation, and that this effect of diquat is not seen at a dose level of 0.5mg/kg.
麻布大学の論文