Resetting Mechanism of Central and Peripheral Circadian Clocks in Mammals
スポンサーリンク
概要
- 論文の詳細を見る
Almost all organisms on earth exhibit diurnal rhythms in physiology and behavior under the control of autonomous time-measuring system called circadian clock. The circadian clock is generally reset by environmental time cues, such as light, in order to synchronize with the external 24-h cycles. In mammals, the core oscillator of the circadian clock is composed of transcription/translation-based negative feedback loops regulating the cyclic expression of a limited number of clock genes (such as Per, Cry, Bmal1, etc.) and hundreds of output genes in a well-concerted manner. The central clock controlling the behavioral rhythm is localized in the hypothalamic suprachiasmatic nucleus (SCN), and peripheral clocks are present in other various tissues. The phase of the central clock is amenable to ambient light signal captured by the visual rod-cone photoreceptors and non-visual melanopsin in the retina. These light signals are transmitted to the SCN through the retinohypothalamic tract, and transduced therein by mitogenactivated protein kinase and other signaling molecules to induce Per gene expression, which eventually elicits phase-dependent phase shifts of the clock. The central clock controls peripheral clocks directly and indirectly by virtue of neural, humoral, and other signals in a coordinated manner. The change in feeding time resets the peripheral clocks in a SCN-independent manner, possibly by food metabolites and body temperature rhythms. In this article, we will provide and overview of recent molecular and genetic studies on the resetting mechanism of the central and peripheral circadian clocks in mammals.
- 社団法人日本動物学会の論文
- 2004-04-25
著者
-
Fukada Yoshitaka
Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo
-
Fukada Yoshitaka
Department Of Biophysics Biochemistry Graduate School Of Science The University Of Tokyo
-
Hirota Tsuyoshi
Department Of Biophysics Biochemistry Graduate School Of Science The University Of Tokyo
-
Hirota Tsuyoshi
Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo
関連論文
- Molecular Cloning and Characterization of a cDNA Encoding the Retinal Arylalkylamine N-Acetyltransferase of the Rainbow Trout, Oncorhynchus mykiss
- LOCALIZATION OF CRY4, A NOVEL BLUE-LIGHT PHOTORECEPTOR-LIKE PROTEIN, IN THE CHICKEN PINEAL GLAND(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- A NOVEL PHOTORECEPTOR CANDIDATE EXPRESSED IN THE CHICKEN RETINA AND PINEAL GLAND(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- ENZYMATIC PROPERTIES OF THE OPSIN KINASE IN THE ZEBRAFISH CONE CELLS(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Immunohistochemical Localization of Opsins and Alpha-Subunit of Transducin in the Pineal Complex and Deep Brain of the Japanese Grass Lizard, Takydromus tachydromoides(Physiology)
- Immunoreactivities to Rhodopsin and Rod/Cone Transducin Antisera in the Retina, Pineal Complex and Deep Brain of the Bullfrog, Rana catesbeiana
- Production of N-Lauroylated G Protein α-Subunit in Sf9 Insect Cells : The Type of N-Acyl Group of Gα Influences G Protein-Mediated Signal Transduction
- A CLOCK-RELATED GENE Lcg EXPRESSED IN THE CHICKEN PINEAL GLAND(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- ANALYSIS OF PUTATIVE CLOCK-RELATED GENES INDUCED BY LIGHT IN A PHASE-DEPENDENT MANNER(Physiology&Biochemistry,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Light-Dependent Changes in the Chick Pineal Temperature and the Expression of cHsp90αgene : A Potential Contribution of in vivo Temperature Change to the Photic-Entrainment of the Chick Pineal Circadian Clock(Physiology)
- REGULATION OF PHOTOTRANSDUCTION BY SELECTED FARNESYLATION OF PHOTORECEPTOR G PROTEIN γ-SUBUNIT(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Regulatory Mechanism for the Stability of the Meta II Intermediate of Pinopsin
- The Differences in the Expressions of Visual Pigments and Transducin in Photoreceptor Cell Differentiation
- Functional Role of Melatonin in the Formation of Circadian Rhythms in the Zebrafish(Oscillatory Mechanisms and Functional Differentiation of Circadian Clocks,Symposium,PROCEEDING OF THE 76^ ANNUAL MEETING OF THE ZOOLOGICAL SOCIETY OF JAPAN)
- Effect of Brefeldin A on Melatonin Secretion of Chick Pineal Cells^1
- Chicktacking Pineal Clock
- SCREENING FOR TRANSCRIPTION FACTORS REGULATING THE ZEBRAFISH PINEAL PHOTORECEPTOR CELL DIFFERENTIATION(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- COMPARISON OF GENE EXPRESSION PROFILES BETWEEN THE ZEBRAFISH PINEAL AND RETINAL PHOTORECEPTOR CELLS(Physiology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- TRANSGENIC ZEBRAFISH EXPRESSING DOMINANT NEGATIVE MUTANT OF zfBMAL IN THE PINEAL GLAND(Physiology&Biochemistry,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- PIPE : A NOVEL CIS-ACTING ELEMENT RESPONSIBLE FOR PINEAL-SPECIFIC GENE EXPRESSION IN THE ZEBRAFISH(Physiology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- IN VIVO ANALYSIS OF THE ZEBRAFISH Bmal FUNCTION IN THE PINEAL CLOCK SYSTEM(Physiology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- ESTABLISHMENT OF TRANSGENIC ZEBRAFISH HAVING PIPE-INDUCING GFP EXPRESSION IN THE PINEAL GLAND(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Molecular Oscillation Behind the Clockface
- ROLE OF MAP-KINASE IN THE OSCILLATION MECHANISM OF THE CHICKEN PINEAL CIRCADIAN CLOCK(Physiology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Resetting Mechanism of Central and Peripheral Circadian Clocks in Mammals
- W4-4 Chick Pineal Circadian Clock : The Clock Genes and Photoentrainment.
- Production of N-Lauroylated G Protein .ALPHA.-Subunit in Sf9 Insect Cells: The Type of N-Acyl Group of G.ALPHA. Influences G Protein-Mediated Signal Transduction