Stereoselectivity in the Mechanism of Acid Hydrolysis of Mitomycins(Analytical,Chemical)

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概要

• 論文の詳細を見る

• The stereoselectivity in the acid hydrolysis mechanism of mitomycins was studied. The predominance of the 1,2-cis-mitosene degradation products occurring at low pH was ascribed to the directing force exterted on the incoming nucleophile by the protonated 2-amino function of an intermediate in the process as well as to steric hindrance due to the orientation of the C_9 urethane substituent in one of the degradation steps preceding the formation of the intermediate. The differences in electron density in the intermediate chrornophore and the resulting differences in pK_a value of the amino function involved are discussed.

• 公益社団法人日本薬学会の論文
• 1987-11-25

著者

• Underberg W

  Utrecht Univ. Utrecht Nld

• UNDERBERG Willy

  Department of Biomedical Analysis, Faculty of Pharmaceutical Sciences, Utrecht University

• BEIJNEN JOS

  The Netherlands and Slotervaart Hospital Netherlands Cancer Institute

• Underberg Willy

  Department Of Analytical Pharmacy Subfaculty Of Pharmacy State Univeristy Of Utrecht.

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