腎不全患者の赤血球糖代謝に関する研究 : 特に2,3-diphosphoglycerateの変動を中心として
スポンサーリンク
概要
- 論文の詳細を見る
Studies were performed which suggest alterations of 2, 3-diphosphoglycerate (2, 3-DPG) and glycolytic enzyme activities in the red blood cells of uremic patients undergoing a long term-or non-hemodialysis regimen, with a view to making a study of their clinical significance. 2,3-DPG level in uremic subject undergoing long term hemodialysis was significantly greater than that of normal subject. However, there was no noticeable difference between non-hemodialytic and normal patients. Red blood cells from utemic subjects showed a significant increase in the activities of phosphofructokinase and pyruvatekinase. Furthermore, glucose utilization of red blood cells was accelerated. Moreover, plasma and red blood cells from normal or uremic subjects were separated, and incubated by combining each interchangeably. The influences upon red blood cell glycolytic metabolism during incubation were studied. Only when the red blood cells from normal subject were added to the plasma from uremics, was a considerable increase in 2, 3-DPG and an acceleration in glucose utilization observed. These results indicated there existed a certain factor in the plasma from uremic subjects which increased 2, 3-DPG levels. When measured before and after hemodialysis in many cases, there was a decrease after each hemodialysis. As the above results, it was considered possible that in uremic plasma there was a certain factor which promoted red blood cell glycolysis and higher 2,3-DPG levels, adapting to uremic hypoxia. It was also acertained that this was related to shortening of the red blood cell's half life in uremic patients.
著者
関連論文
- 腎不全患者の赤血球糖代謝に関する研究 : 特に2,3-diphosphoglycerateの変動を中心として
- Studies on the Metabolism of Erythrocyte for Tissue Hypoxia and its Clinical Application