メラトニンの胎児抗酸化能増強作用に関する研究
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概要
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Melatonin (MLT) is highly ubiquitous direct free radical scavenger and indirect antioxidant. This study was designed to evaluate maternal-fetal transfer of MLT and stimulatory effect of MLT on antioxidant status in fetus. MLT (6 mg) was administered orally to healthy nonpregnant volunteers and pregnant women who received elective Cesarean section. MLT was administered 2h or 4h before delivery. Blood from non-pregnant women were obtained 1h, 2h and 4h after MLT administration. Blood from maternal vein and umbilical vein were obtained at delivery. Plasma MLT concentration in volunteers increased markedly at 1h (20.27±1.32ng/ml) compared with the value prior to MLT administration (0.031±0.01ng/ml) and showed the same level until 4h. Plasma total antioxidant status (TAS) also significantly increased at 1h (1.229±0.065mM/l) compared with the pre-treatment level (0.984±0.030mM/l). Plasma MLT concentration in maternal vein markedly increased at 2h (17.83±1.64ng/ml) and decreased at 4h (13.46±1.61ng/ml). Plasma TAS also significantly increased at 2h (1.250±0.044mM/l) compared with the group without MLT treatment (1.018±0.074mM/l). Plasma MLT and TAS levels in umbilical vein also significantly increased at 2h (17.36±2.64ng/ml, 1.444±0.060mM/l) compared with the group without MLT treatment (0.024±0.001ng/ml, 1.079±0.039 mM/l). These results suggest that MLT readily cross placenta and increase antioxidant activity in fetus. The results also suggest that MLT may have potential clinical applicability for preeclampsia and fetal distress where excess of free radicals are involved in the pathology.
- 高知大学の論文
- 2003-09-30
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