水頭症病態における脊髄中心管の形態と機能に関する研究
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概要
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Obstruction of cerebrospinal fluid pathways produces many changes in the parenchyma of the brain and spinal cord. Spinal central canal of a murine model of hydrocephalus (hy-3) and puppy hydrocephalus by cisternal kaolin injection, were correlated with events occuring in the intracranial compartment. The central canal of hy-3 mice was enlarged in hydrocephalic mice. Plugging of the the obex resulted in a collapse of the central canal. Tracer study of ferritin by electron microscope demonstrated transependymal movement of tracer throughout the central canal. Puppy hydrocephalus disclosed moderate enlargement both in the ventricle and central canal. When the central canal was occluded by ligating the filum terminale, the degree of enlargement both in the ventricle and central canal became more severe. These findings suggeted that hydrodynamic stresses transmitted from the ventricle down to the central canal through the obex. And this hydrodynamic stresses consisted of the pulsatile action of choroid plexus and static pressure in the ventricle. Also the dilated central canal migght be functioning as an alternate c. s. f. pathways in order to drainage the c. s. f. from the ventricle to the lumbar subarachnoid space. Based on these experimental studies, it is logical to do either ventriculo-peritoneal shunt operation or terminal ventriculostomy (opening of the filum terminale) for communicating syringomyelia, which has the communication between lateral ventricle and syrinx through the central canal.
- 神戸大学の論文