歯周疾患患者血清中の抗Bacteroides asaccharolyticus抗体について

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Some species of gram-negative anaerobic bacteria have been shown to play an important role in the pathogenesis of inflammatory periodontal disease. In these organisms Bacteroides asaccharolyticus has been found predominantly in the subgingival plaque which was obtained from patients with adult or generalized juvenile periodontitis. There are some evidence that this organism might elicite humoral immune response during the course of periodontal disease by passing the capsule through pocket epithelium. An enzyme-immunoassay, which was sensitive enough to determine low amoumt of antibody was used for measuring serum antibody titer specific for B. asaccharolyticus (strain 381). The serum was obtained from 16 patients with periodontal disease and 14 subjects with healthy periodontal tissue. Various clinical parameters were measured from these patients and subjects at that time. Following results were obtained. 1. The diseased group showed significantly higher antibody titer specific for B. asaccharolyticus than the healthy group. (P<0.05) 2. Concerning the relation between the alveolar bone loss and the antibody titer, it was found that severe bone loss group (more than 40%) had greater antibody titer than minimal bone loss group. 3. A correlation between severity of disease and the increase of antibody titer was also positively observed, but significant difference was not stastically obtained. These results indicate the passage of the bacterial components through pocket epithelium and the production of the specific humoral antibody on the patients with periodontal disease. This specific antibody may play protective role, however destructive effects of the immunological reaction should be also considered.
特定非営利活動法人日本歯周病学会の論文
1982-03-28

歯周疾患患者血清中の抗Bacteroides asaccharolyticus抗体について

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