経口投与したコンドロシンのラット軟骨への^<35>S硫酸取り込み効果

概要

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Chondroitin sulfate is widely distributed in animal tissues and possibly plays an important role in different types of metabolic reactions as well as protecting joints, the internal wall of blood vessels, skin, bone, etc. In cartilage, glycosaminoglycans have a protective function; in particular, chondroitin sulfate stabilizes fibrous and cellular elements of the connective tissue and, at the same time, lubricates and protects the membranes in joints. Recently, chondroitin sulfate has been used as a nutraceutical for the treatment of joint diseases such as osteoarthritis, although acidic and large molecules such as chondroitin sulfate might not be able to be absorbed through digestive apparatus such as the intestine. In this study, we investigated the effects of orally administered chondrosine derived from shark chondroitin sulfate on the uptake of inorganic ^<35>S sulfate into rat cartilage and found that chondrosine stimulates the incorporation of ^<35>S sulfate into cartilage compared with intact chondroitin sulfate.
社団法人日本薬学会の論文
2006-04-01