D-Allele of ACE Polymorphism is Associated With Increased Magnitude of QT Dispersion Prolongation in Elderly Chinese : 4-Year Follow-up Study
スポンサーリンク
概要
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Background There has not been a longitudinal investigation of the influence of angiotensin-converting enzyme (ACE) insertion/deletion and angiotensinogen (AGT) M235T gene polymorphisms on repolarization parameters, such as QT dispersion (QTd) and the peak and the end of the T-wave interval (Tpe). Methods and Results Electrocardiographys were recorded from 106 elderly Chinese at baseline, and 2^<nd> and 4^<th> year follow-up. The corrected QT (QTc), QTd, QTc dispersion (QTcd) and Tpe were manually calculated. Average age was 72.7±4.1 years (range 62-81). QTd, QTcd and Tpe were significantly prolonged (all p<0.001 at the 2^<nd> and 4^<th> year). At the 4^<th> year the magnitude of the QTd prolongation, but not Tpe, was significantly higher in subjects carrying the ACE D allele than non-D-allele carriers (p=0.001), as was QTcd (p=0.002). This association was still significant in the multivariate analyses (p<0.001 and p=0.001 for QTc and QTcd, respectively). No significant correlation was found between repolarization parameters and AGT genotype. Conclusions This longitudinal study shows that the ageing process is associated with prolongation of QTd, QTcd and Tpe after 4 years follow-up. The elderly Chinese subjects with the ACE D-allele had greater prolongation QTd and QTcd.
- 社団法人日本循環器学会の論文
- 2006-12-20
著者
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Lai Wen-ter
Division Of Cardiology Department Of Internal Medicine Kaohsiung Medical University Hospital
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LIN Tsung-Hsien
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaoh
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VOON Wen-Chol
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaoh
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SU Ho-Ming
Division of Cardiology, Kaohsiung Medical University Hospital, Kaohsiung Medical University
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Su Ho-ming
Department Of Internal Medicine Kaohsiung Municipal Hsiao-kang Hospital Kaohsiung Medical University
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Voon Wen-chol
Division Of Cardiology Department Of Internal Medicine Kaohsiung Medical University Hospital Kaohsiu
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LEE Ya-Ting
Division of Nephrology, Department of Pediatrics, Department of Internal Medicine, Kaohsiung Medical
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SHEU Sheng-Hsiung
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital
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Chiu Herng-Chia
Public Health, Kaohsiung Medical University
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Juo Suh-Hang
Medical Genetics, Kaohsiung Medical University
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Lin Tsung-hsien
Division Of Cardiology Department Of Internal Medicine Kaohsiung Medical University Hospital Kaohsiu
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Chiu Herng-chia
Division Of Nephrology Department Of Internal Medicine Kaohsiung Medical University Hospital Kaohsiu
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Juo Suh-hang
Division Of Nephrology Department Of Internal Medicine Kaohsiung Medical University Hospital Kaohsiu
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Sheu Sheng-hsiung
Division Of Cardiology Department Of Internal Medicine Kaohsiung Medical University Hospital
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Lee Ya-ting
Division Of Nephrology Department Of Pediatrics Department Of Internal Medicine Kaohsiung Medical Un
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Lin Tsung-hsien
Division Of Cardiology Department Of Internal Medicine
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Voon Wen-chol
Division Of Cardiology Department Of Internal Medicine
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SU Ho-Ming
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital
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