コホート研究による推定栄養素摂取量と肺がん死亡との関連
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概要
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Using data from a cohort study in an area of Japan, relationships between estimated nutritional intake and risk of lung cancer death were analyzed. Subjects were residents aged over 35 years in a city of Nagano Prefecture, who answered a questionnaire concerning smoking and drinking habits, past history and frequency of food intake in 1989. Intakes of energy, protein, lipids, carbohydrates, carotene, retinol, and vitamins C and E were estimated for each subject from the frequency of food intake. Those with a history of malignancy or with insufficient answers on food intake were excluded and 26,018 subjects were followed up from 1989 to 1999. Relationships between the estimated nutritional intake and lung cancer death were analyzed separately by gender using a proportional hazard models adjusted for age, energy intake, smoking and drinking habits. In both genders, smoking elevated the risk of lung cancer death, but drinking showed no association. In male subjects, energy intake was positively related with a hazard ratio (HR) of 3.9 between the highest and lowest tertiles (p for trend <0.05): for retinol, both the intermediate and highest tertiles showed a smaller risk compared with the lowest tertile, the former of which was significant. In female subjects, intake of protein (HR was 6.1 between the highest and lowest tertiles, and p for trend was <0.01) and lipid (HR=6.3. p for trend <0.01) were positively related and intake of carbohydrate was negatively related (HR=0.16. p for trend <0.01) to the risk of lung cancer death. Vitamins C and E showed a negative but statistically insignificant relationship with the risk of lung cancer death in both male and female subjects.
- 愛知医科大学の論文
- 2005-12-15