細胞内及び細胞外における細菌認識と自然免疫活性化(誌上シンポジウム)

概要

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One of the fundamental questions in innate immunity is how a large battery of invading pathogens is recognized by a limited number of germ line-encoding receptors. In Drosophila, peptidoglycan recognition protein (PGRP) family members have a crucial role in recognizing invading bacterial pathogens and in inducing immune reactions. PGRP-SA, -SD, and -SCla are involved in recognizing gram-positive bacteria and in activating the Toll pathway to produce antimicrobial peptides. PGRP-LC and -LE recognize diaminopimelic acid (DAP)-containing peptidoglycans, which are cell wall components of many gram-negative bacteria and some gram-positive bacteria, and activate the imd pathway to produce antibacterial peptides. In addition to the extracellular function of PGRP-LE to activate immune reactions in the hemolymph, PGRP-LE acts as an intracellular receptor for monomeric DAP-type peptidoglycans. Moreover, a version of PGRP-LE containing only the PGRP domain functions extracellularly as a CD14-like accessory factor, capable of enhancing PGRP-LC-mediated peptidoglycan recognition. Subsequent intracellular signaling is transduced through the RHIM-like motif found in PGRP-LC and -LE.
公益社団法人日本薬学会の論文
2006-12-01