歯周疾患の発症と進行における白血病の役割

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Leukocytes are involved in the cellular and humoral defense of the organism against foreign material. The protective function of the leukocytes is demonstrated by the fact that the patients with leukocyte disorders present unusually rapid and severe periodontal disease. In addition, the patients with early onset or rapidly progressing forms of periodontal disease often exhibit relatively subtle leukocyte defects. Granulocytes, comprised in the leukocytes, have two distinct cytoplasmic lysosomal granules that contain specific enzyme activities capable of degrading bacterial cell walls as well as host tissues. A variety of proteases released from granulocytes may play a destructive role in periodontal tissue components. Much has examined the potential of measuring levels of various substances found in gingival crevicular fluid (GCF) as indicators of periodontal disease progression. The levels of elastase and cathepsin G discharged from lysosome of granulocyte are elevated in the GCF of the patients with gingivitis and periodontitis. The activity of these enzymes is modulated by specific inhibitors either locally or circulating in plasma. Our investigation that examined the possible relationship between periodontal clinical parameters and GCF elastase, cathepsin G and their inhibitor complex levels may be developed to clarify the periodontal disease activity. HLA system, regulating the immune response, have been found to be associated with various diseases, especially autoimmune diseases. Several studies have demonstrated the linkage between HLA system and early onset and rapidly progressing forms of periodontal disease. HLA system may be associated with low or non-responsiveness to plaque bacterial antigens which could result in disease progression.
鹿児島大学の論文
1993-03-25

歯周疾患の発症と進行における白血病の役割

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