Design and Evaluation of Jingzhiguanxin Monolithic Osmotic Pump Tablet

スポンサーリンク

概要

• 論文の詳細を見る

• A monolithic osmotic pump tablet (MOPT) of Traditional Chinese Medicine Compound Recipe (TCMCR) was successfully prepared and active components of Jingzhiguanxin prescription which has been widely used in China and Japan was selected as model drug. Analysis methods of maker compound in vitro of danshensu, paeoniflorin and safflor yellow A were built, and different methods were compared by f_2 factors. The results showed that there were fine correlation among them. Finally UV method of safflor yellew A was chosen to determine the release of the drugs, which was fast, convenient, met the need of determination and could represent other methods. During the research, single factor influence selection was studied emphatically. It showed that there were significant influence between different varieties and quantity of osmotic promoting agents, different kind of retardants, different varieties and quantity of PEG (polyethylene glycol) and membrane weight. However, no significant influence existed between different quantity of retardants and SDS, different membrane orifices and methods of dissolution. Based on the single factor influence selection, an optimal formulation was decided, and three maker compounds of Jingzhiguanxin MOPT could isochronous release and at the same time they had good zero order release characteristics to 8h. Paeoniflorin release in vivo was estimated by deconvolution, the results shown that there were a good in-vitro in-vivo correlation (r=0.9571).

• 公益社団法人日本薬学会の論文
• 2006-04-01

著者

• LI Wei

  School of Life Science and Technology, Beijing Institute of Technology

• Liu Zhi-dong

  School Of Pharmacy Shenyang Pharmaceutical University

• Pan Wei-san

  School Of Pharmacy Shenyang Pharmaceutical University

• Li Wei

  Dep. Of Pharmaceutical Sciences Coll. Of Pharmacy The Univ. Of Tennessee Health Sci. Center

• YANG Xing-Gang

  School of Pharmacy, Shenyang Pharmaceutical University

• ZHANG Guo-Hua

  Adult Education Institute, Shenyang Pharmaceutical University

• PENG Bo

  School of Pharmacy, Shenyang Pharmaceutical University

• Yang Xing-gang

  School Of Pharmacy Shenyang Pharmaceutical University

• Peng Bo

  School Of Pharmacy Shenyang Pharmaceutical University

• Zhang Guo-hua

  Adult Education Institute Shenyang Pharmaceutical University

• Li Wei

  School Of Chemical Engineering And Technology Tianjin University

• Li Wei

  School Of Pharmacy Shenyang Pharmaceutical University

関連論文

• Antihyperglycemic Effect of Cephalotaxus sinensis Leaves and GLUT-4 Translocation Facilitating Activity of Its Flavonoid Constituents(Pharmacognosy)
• Somatostatin receptor-1 induces cell cycle arrest and inhibits tumor growth in pancreatic cancer
• Effect of TiB Whiskers Orientation on Mechanical Properties in an In Situ TiB/Ti-1100 Composite
• Design and Evaluation of Jingzhiguanxin Monolithic Osmotic Pump Tablet
• High-Efficiency White Organic Light-Emitting Diodes Based on Phosphorescent Iridium Complex and 4,4'-Bis[N-1-napthyl-N-phenyl-amino]biphenyl Emitters
• Application of Brown-Rot Basidiomycete Fomitopsis sp. IMER2 for Biological Treatment of Black Liquor(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• Preparative chromatographic purification of diastereomers of silybin and their quantification in human plasma by liquid chromatography-tandem mass spectrometry
• High-Efficiency White Organic Light-Emitting Diodes Based on Phosphorescent Iridium Complex and 4,4$'$-Bis[N-1-napthyl-N-phenyl-amino]biphenyl Emitters
• 608 Late Cretaceous spores and pollen assemblages and palaeoclimate of the lower Nenjiang Formation in the Songliao Basin, NE China

スポンサーリンク