抗痙れん剤長期服薬児における遊離型血中濃度に関する臨床薬理学的研究 : とくに血清アルブミン濃度の影響

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The free fractions of phenobarbital and valproic acid were assayed with Free-Level system I (Syva) and by an enzymatic immunoassay technique (EMIT) in 186 patients under chronic anticonvulsant therapy at precisely 2 hours after they had taken the medicine at breakfast. The free fre fractions of PB ranged from 49 to 53 percent in monopharmacy and from 50 to 55 percent in polypharmacy. Those of VPA ranged from 10 to 12 percent in monopharmacy and from 8 to 11 percent in polypharmacy. The regression lines of the free fractions in PB monopharmacy and PB polyphharmacy against serum albumin concentration indicated a- negative correlation. There was no difference between the free fractions in PB monopharmacy and polypharmacy at the same albumin concentration. The regression lines of the free fractions in VPA monopharmacy and polypharmacy against serum albumin concentration indicated a negative correlation. The free fractions of VPA did not vary under a total VPA concentration of 80 μg/ml while those of VPA above a total VPA concentration of 90 μg/ml increased with the total concentration, in the monopharmacy groups. On the other hand, free fractions of VPA in the polypharmacy groups did not vary with the total VPA concentration.
神戸大学の論文