慢性閉塞性肺疾患患者の運動耐容能におよぼす酸素およびニトログリセリンの効果

概要

論文の詳細を見る
One minute incremental exercise test and 6 min single stage exercise test on a bicycle ergometer were performed in 11 patients with chronic obstructive pulmonary disease (COPD), and the effects of 30 percent oxygen breathing and sublingual administration of nitroglycerin (NTG) on exercise capacity were evaluated. For assessing the exercise capacity, aerobic work capacity was measured in these patients by determining the maximum oxygen consumption (Vo_2max) and the anaerobic threshold (AT), expressed as the highest oxygen consumption above which sustained lactic acidosis occured. In these patients, AT and Vo_2max was significantly increased by either oxygen breathing or sublingual administration of NTG. These improvements were considered to be induced by different mechanisms, i. e. in cases with oxygen breathing by a relief of hypoxemia and tissue hypoxia during exercise and in cases with NTG by an increase in A-Vo_2 difference, which was possibly caused by a preferential redistribution of cardiac output to working muscles. In conclusion, it was revealed that in patients with COPD, either oxygen breathing or sublingual administration of NTG was effective in terms of an increase in the aerobic work capacity.
神戸大学の論文