Effect of SstI Polymorphism of the Apolipoprotein CIII Gene and Environmental Factors on Risks of Hypertriglyceridemia in Taiwan Aborigines

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概要

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• Background Hypertriglyceridemia (HTG) is a heterogeneous metabolic disorder. The aim of this study was to examine associations among genetic polymorphisms, SstI polymorphism of apolipoprotein CIII (ApoCIII) and Hind III polymorphism of lipoprotein lipase (LPL), environmental factors and risks of HTG. Methods and Results Two hundred and forty-nine southern Taiwanese aborigines were recruited for a crosssectional study, which included 90 subjects with triglyceride (TG) >150mg/dl (HTG) and 159 with TG ≤150mg/dl (NTG). The frequencies of SstI major allele (S1) and minor allele (S2) of ApoCIII were 66.1% and 33.9% in HTG and 73.6% and 26.4% in NTG (p<0.1). In female subjects, the frequencies of the S2 allele was significantly higher in HTG (0.38) than NTG (0.27) (p<0.04). The frequencies of the LPL HindIII major allele (H+) and minor allele (H-) were similar between HTG (H+84.3%; H-15.7%) and NTG (H+78.9%; H-21.1%). In a multivariate adjusted logistic model, education ≤6 year (odds ratio (OR)=3.71, 95% confidence interval (CI): 1.24-8.13), Amis tribe (OR=3.08, 95% CI: 1.41-6.77), body mass index (BMI) ≥25 (OR=2.22, 95% CI: 1.18-4.16), starchy food consumption ≥3 times/week (OR=1.89, 95% CI: 1.00-3.59) and ApoCIII S2S2 genotype (OR=3.35, 95% CI: 1.10-10.19) were independently (p<0.05) associated with HTG risks. Among ApoCIII S1S1, S1S2 and S2S2 genotypes, ApoCIII and TG concentrations increased (p<0.01) in a dose-responsive manner. Conclusions The ApoCIII S2 variant and environmental factors, including education, tribal background, BMI and starchy food intake, modulate the risks of HTG in aboriginal Taiwanese. Interaction between genetic and environmental factors warrants further investigation.

• 社団法人日本循環器学会の論文
• 2006-07-20

著者

• Tu Hung-ping

  Department Of Public Health School Of Medicine Kaohsiung Medical University

• Chang Wen-tsan

  Department Of Biotechnology Chia Nan University Of Pharmacy And Science

• Chang Wen-tsan

  Department Of Surgery Kaohsiung Medical University Chung-ho Memorial Hospital

• Wang Tsu-nai

  School Of Public Health Kaohsiung Medical University

• Ko Ying-chin

  Department Of Public Health School Of Medicine Kaohsiung Medical University:division Of Environmenta

• Ko Ying-chin

  Department Of Public Health Kaohsiung Medical University

• Huang Meng-Chuan

  Department of Public Health, School of Medicine, Kaohsiung Medical University

• Liu Yi-Ling

  Department of Public Health, School of Medicine, Kaohsiung Medical University

• Pa Te-Hsiung

  Taimali Township Public Health Center

• Huang Yi-Chia

  School of Nutrition, Chung Shan Medical University

• Huang Meng-chuan

  Department Of Public Health School Of Medicine Kaohsiung Medical University:department Of Nutrition

• Liu Yi-ling

  Department Of Public Health School Of Medicine Kaohsiung Medical University

• Huang Yi-chia

  School Of Nutrition Chung Shan Medical University

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• Molecular analysis of mutations and polymorphisms of the Lewis secretor type α(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation
• Cavernous Hemangioma of the Pancreas : Report of a Case
• Effect of SstI Polymorphism of the Apolipoprotein CIII Gene and Environmental Factors on Risks of Hypertriglyceridemia in Taiwan Aborigines

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