大強度陽子加速器中性子源を活用した生物研究の展望

概要

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J-PARC (Japan Proton Accelerator Research Complex) is now under construction. The facility promises to deliver neutron intensities that are at least an order of magnitude (or more) higher than those at existing sources: traditional nuclear reactors such as JRR-3 in JAEA. New prospects for neutron in biology with use of a diffractometer (BIX-P1), small angle scattering (HI-SANS) and inelastic scattering spectrometer (DIANA) will be proposed. BIX-P1 will provide new insight of nature of the chemical bonds and molecular recognition mechanism in proteins on the basis of hydrogen and hydration in proteins. HI-SANS will open a new horizon for studying multi-component biological systems in whole hierarchal levels. DIANA will reveal the dynamical properties of proteins with relation to the hydration water and will be intensively used to direct the application such as drug design.
日本生物物理学会の論文
2006-07-25