Spontaneous Formation of Cell Clusters in a Cardiac Cell Culture System(Oscillation, Chaos and Network Dynamics in Nonlinear Science)

概要

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Spontaneous formation of cell clusters was experimentally studied for a cardiac cell culture system. A primary cell culture prepared from a newborn rat was cultivated and continuously observed using microscopy. It was found that the cells start to form small clusters following which a transient network of clusters was formed. Finally, the network structure was fragmented into distinct large clusters. The formation of these structures was found to proceed on a timescale of one week. Since it was found that addition of a chemical that inhibits the beating motion of cardiac cells into the culture medium suppresses the cluster formation, it has been deduced that the mechanical tension attributed to the beating motion of the cardiac cells drives the formation of clusters. The details of the experimental results are presented along with the present model on the mechanism.
理論物理学刊行会の論文
2006-04-20