辺縁性歯周炎のポケット上皮における線維素溶解現象の発生機序に関する病理組織学的並びに組織化学的研究

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概要

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• The present study has been performed to elucidate the mechanism of fibrinolysis of the crevicular epithelium in marginal periodontitis, on the gingival tissues including crevicular wall from the operated materials, pocket contents, and cultivated oral bacteria. For this purpose, fibrinolysis autography by Todd, Gram-Weigert staining for fibrin and bacteria, and control procedures by inhibitors and other factors were applied. The following results were obtained: 1. In marginal periodontitis, fibrinolysis was observed in the crevicular epithelium in 100 per cent. However, there was no distinct correlation between fibrinolysis of the crevicular epithelium and perivascular fibrinolysis in subepithelial inflammatory focus of the crevicular wall. 2. The fibrinolysis was found almost invariably in some part of all bacterial plaques examined, but not always in desquamated epithelial cells, polymorph nucleated leucocytes and macrophages. 3. The fibrinolysis was not induced by cultivated Streptococci Group A and C alone which produce streptokinase, and by cultivated Bacteroides melaninogenicus alone which elavorates some kinase like streptokinase. 4. Basing on these findings, it was concluded that the fibrinolysis of the crevicular epithelium has some relation with bacterial plaque in the pocket, but cannot be attributed to oral bacteria alone. 5. The following possibility was discussed that the streptokinase from the bacterial plaque can combine with plasminogen present in pocket exsudate leading to production of a streptokinase-plasminogen complex, a potent activator and then the latter plays an important role in mechanism of the fibrinolysis of the crevicular epithelium in marginal periodontitis. 6. Additionally, it was presumed that the plasmin activated from the plasminogen in the pocket also contributes to produce kinin and cloven products from the third component of complement, resulting in increased vascular permeability and chronic exudative inflammation in marginal periodontitis.

• 特定非営利活動法人日本歯周病学会の論文
• 1979-12-28

著者

• 鈴木 健

  鶴見大学歯学部病理学教室

• 鈴木 健

  東京医科歯科大学難治疾患研究所 機能病理学部門

関連論文

• 19.辺縁性歯周炎におけるポケット内線溶能のポケット壁滲出性炎に及ぼす影響(第25回 秋季日本歯周病学会)
• 辺縁性歯周炎のポケット上皮における線維素溶解現象の発生機序に関する病理組織学的並びに組織化学的研究
• 6.辺縁性歯周炎の場合炎症の中心とその拡大と消退様式に関する病理組織学的研究(第22回 春季日本歯周病学会)
• 9.辺縁性歯周炎のポケット上皮の透過性に関する病理組織学的,組織化学的研究(第21回 秋季日本歯周病学会)
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• 15.口腔粘膜に作用する刺激における急性炎症の上皮下結合組織における肥満細胞と不溶性コラゲンの変化(第2回 日本歯周病学会例会一般講演要旨)
• 10.炎症時における歯肉上皮,上皮付着,歯肉嚢上皮の浸透性について(第16回 日本歯周病学会総会一般講演要旨)

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