DMBA誘導ハムスター舌腫瘍形成過程における細胞性免疫能の検討 : DNCB遅延型皮膚反応および腹腔マクロファージの機能(Superoxide 産生能)について
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Cellular immunity in DMBA induced hamsters' tongues neoplasia formation was studied utilizing DNCB delayed type hypersensitivity (DTH) reaction and superoxide production ability of peritoneal macrophage of hamsters. DNCB-DTH reactions were examined on 119 3-months-old male hamsters, which were categorized as DMBA treated, untreated normal, steroids-treated normal, anti-carcinoagents treated normal, radiation-exposed normal. While 94.9% of the untreated normal hamsters showed a positive reacton to DNCB-DTH, the DMBA treated hamsters' DNCB-DTH reaction rose from 90% to 94.7%. From this it might be surmised that there existed an antigeneicity which was common to both DMBA and DNCB. Therefore, in the DMBA carcinogenic experiment, it is of no use utilizing DNCB-DTH reaction in the experiment of cellular immunity. DNCB-DTH reaction was not suppressed in the normal hamsters which were injected steroids and anticarcinoagents into the peritoneal cavity. On the other hand, it was recognized that DNCB-DTH reaction was suppressed in the irradiated hamsters. With 224 5-weeks-old hamsters: DMBA treated, untreated, or dosed, superoxide production ability of peritoneal macrophage was examined utilizing NBT reduction method. Superoxide production ability of the DMBA treated group in the eleventh week was considerably low compared with the untreated control group in the same period. This period corresponds to the period of neoplasia autonomic increase aquisition reported by Shigeoka and his co-researchers. The anesthetized group in the eleventh week also showed a considerably less ability than the untreated-control group of the same period. The influence of Ether anesthesia used for carcinogenic manipulation on immunity cannot be ignored. By dosing OK432, SPG, BLM, FT207 up to the eleventh week, superoxide production ability of the hamsters; the normal untreated, the Ether anesthetized, and the carcinogenic manupulated, was examined. The normal untreated hamsters with the hypodermic injection of OK432 increased the superoxide production ability. In addition, OK432 prevents a suppression of superoxide production ability caused anesthesia and carcinogenic manipulation.
- 神戸大学の論文
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