慢性下顎骨骨髄炎モデルにおける実験的研究
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概要
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Prodution of experimental mandibular osteomyelitis in rabbits with comprehensive quantitative analysis therein of mandibular bone marrow alkaline phosphatase activity and immunoglobulins, along with concentrations of four antibiotics in serum and bone marrow are presented. 1. Of three methods examined to induce experimental mandibular osteomyelitis in rabbits, the electric current method produced the most suitable infection condition (about 100% success rate), with pathological findings confirming the widest destruction of bone marrow and absess formation. 2. In this model, alkaline phosphatase activity in infected and normal sites of bone marrow was compared, with the activity rate at the former 2.19 times that at normal sites after 3 months (P<0.01), and 1.74 times the latter at 6 months (P<0.02). This almost corresponded with osteoid formation in connective tissue surrounding inflammatory tissue in pathological findings. 3. The IgG level in bone marrow was higher at the infection site than at the normal site from 3-6 months after sowing bacteria (P<0.01). The same tendency was seen in IgM levels at a week (P<0.01). 4. Serum levels of of 4 antibiotics were measured over a 15-120min interval following adminitrastion. Timecourse serum concentrations of LCM showed a gradually decreasing tendency, whereas those of CEZ and PIPC decreased rapidly. 1.4-2.2 times higher bone marrow concentrations of the 4 antibiotics were seen at the infection sites than at normal sites 60min after administration.
- 神戸大学の論文