Effect of Sympathetic Nervous System Stimulation on Cerebrovascular CO_2 Responsiveness
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概要
- 論文の詳細を見る
Cerebrovascular CO_2 responsiveness, following noradrenaline (NA) infusion, was studied in the cat by continuous measurement of cerebral tissue oxygen tension (BrPO_2), carbon dioxide tension (BrPCO_2), pH (BrpH), and blood pressure (BP). Intravenous infusion of NA (1μg/kg/min) was done to stimulate the adrenergic nervous system. Inhalation of 5% CO_2+air was performed for 3 minutes before, during, and after NA infusion. Cerebrovascular CO_2 responsiveness was estimated from changes in BrPO_2, BrPCO_2, and BrpH. CO_2 inhalation increased BrPO_2, BrPCO_2, and BP, but decreased BrpH, in the respective 3 stages. ΔBrPO_2 decreased significantly during NA infusion, but recovered after cessation of NA. NA infusion caused a decrease in CO_2 responsiveness. This suggests that sympathetic hyperactivity can modify cerebrovascular CO_2 responsiveness.
- 東海大学の論文
著者
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Fukuuchi Yasuo
慶応義塾大学 内科
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Fukuuchi Y
Keio Univ. Tokyo Jpn
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Fukuuchi Y
Keio Univ.
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Fukuuchi Yasuo
Department Of Neurology Keio University
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Izumi Yoshio
東海大学 神経内科
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Izumi Yoshio
Department Of Neurology Tokai University School Of Medicine
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ISOZUMI Kazuo
Department of Neurology, School of Medicine, Keio University
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Isozumi K
Ashikaga Red Cross Hospital Tochigi Jpn
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Isozumi Kazuo
Department Of Neurology Ashikaga Red Cross Hospital
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