Effect of Diabetic Retinopathy on Redox State of Aqueous Humor and Serum Albumin in Patients with Senile Cataract

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概要

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• Purpose: To investigate the oxidative status of albumin in the aqueous humor and serum of senile cataract patients with diabetes in order to clarify the pathogenesis of this condition. Methods: High-performance liquid chromatography (HPLC) was employed to measure the reduced form of albumin (mercaptalbumin) and the oxidized form of albumin (nonmercaptalbumin) in serum and aqueous humor. The mercaptalbumin, nonmercaptalbumin-1, and nonmercaptalbumin-2 fractions in aqueous humor obtained at the start of cataract surgery and in serum obtained intraoperatively were analyzed by HPLC in 7 senile cataract patients with diabetic retinopathy (2 men and 5 women aged 70±9.8 years). Results: The mean content (%) of mercaptalbumin, nonmercaptalbumin-1, and nonmercaptalbumin-2 in serum albumin from the diabetic patients was 60.3±7.8, 36.9±6.6, and 2.7±1.7%, respectively, while the corresponding values for aqueous humor albumin were 40.0±14.1, 52.4±12.6, and 7.5±3.6%. When the mercaptalbumin content (%) of aqueous humor albumin was compared between patients with active and inactive diabetic retinopathy, the respective values were 47.0±9.1% and 22.8±5.7%. A significant correlation mercaptalbumin content (%) of aqueous humor albumin did not show with the HbAlc level, but there was still a relationship (Y=5.0×-2.7, r=0.80, and p<0.052). Conclusion: The increase of mercaptalbumin (the reduced form of albumin) in the aqueous humor of patients with diabetic retinopathy probably resulted from an increase of retinal vascular permeability.

• 東海大学の論文

著者

• IMAI Hajime

  Department Health and Physical Education, Faculty of Education, Gifu University

• KAWAI Kenji

  Department of Ophthalmology, Tokai University School of Medicine

• Tomida M

  Department Of Physiology Tokyo Women's Medical University

• Tomida Mihoko

  東京女子医科大学 生理学

• Tomida Mihoko

  Department Of Physiology Gifu University School Of Medicine

• Era Seiichi

  Department of Physiology and Biophysics, Gifu University Graduate School of Medicine

• Era S

  Department Of Physiology And Biophysics Gifu University Graduate School Of Medicine

• Era Seiichi

  Gifu Univ. Graduate School Of Medicine Gifu Jpn

• Era Seiichi

  Department Of Physiology And Biophysics Gifu University Graduate School Of Medicine

• Imai Hajime

  Department Health And Physical Education Faculty Of Education Gifu University

• Imai Hajime

  Department Of Biochemistry And Biophysics Gifu University Graduate School Of Medicine

• HAYASHI Tomoya

  Department of Physiology, Meiji University of Oriental Medicine

• NEGAWA Tsuneo

  Department of Physiology and Biophysics, Gifu University Graduate School of Medicine

• KUWATA Kazuo

  Department of Biochemistry and Biophysics Gifu University School of Medicine

• Hayashi T

  Department Of Physiology Meiji University Of Oriental Medicine

• YOH Mutsumi

  Department of Ophthalmology, Ohgaki Municipal Hospital

• SOGAMI Masaru

  Department of Physiology, Gifu University School of Medicine

• Kawai K

  Tokai Univ. School Of Medicine

• Kawai Kenji

  Department Of Ophthalmology Tokai University School Of Medicine

• Negawa T

  Department Of Physiology And Biophysics Gifu University Graduate School Of Medicine

• Hayashi Tomoya

  Department Of Physiology Meiji University Of Oriental Medicine

• Kawai Kenji

  Department Of Physics Faculty Of Science And Technology Sophia University

• Negawa Tsuneo

  Department Of Physiology And Biophysics Gifu University Graduate School Of Medicine

• Yoh Mutsumi

  Department Of Ophthalmology Ohgaki Municipal Hospital

• Sogami Masaru

  Department Of Physiology Gifu University School Of Medicine

• Koda K

  Department Of Ophthalmology Tokai University School Of Medicine

• Tomida Mihoko

  Department Of Oral Physiology Matsumoto Dental University School Of Dentistry

• Hayashi Tomoya

  Department Of Physiology Gifu University School Of Medicine

• Kawai Kenji

  Department Of Civil And Environmental Engineering Hiroshima University

• Tomida Mihoko

  Department Of Oral Physiology Matsumoto Dental University

• Kawai Kenji

  Department of Aquaculture, Kochi University

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