Serum C-peptide Concentration is Useful to Determine Therapeutic Modality for Type 2 Diabetics

概要

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Because the pathophysiology of type 2 diabetes varies in individual patients, the selection of a therapeutic modality depends largely on the empirical judgement of the physician. Facing this situation, there is a need to find an objective index to express the pathophysiology of this disease that can be used in clinical medicine. A prospective study was conducted to determine whether the serum C-peptide level can serve as an effective index for selecting a diabetic treatment. For indices to be used effectively to select therapeutic modalities for type 2 diabetic patients, the fasting C-peptide (CPR) and 2 hours breakfast CPR at the initial examination were determined from a Receiver-operating characteristic (ROC) curve. More than 90% of the patients showing the fasting CPR≧1.4 ng/ml or 2 hours breakfast CPR≧3.3 ng/ml belonged to either group diet or oral hypoglycemic agent; and their blood glucose was successfully controlled without the use of insulin. It was indicated that the CPR level can be used effectively to select an appropriate initial therapeutic modality for type 2 diabetes patients.
北里大学の論文
2002-02-28