腎髄質における尿濃縮機構のコンピュータ・シミュレーション

概要

論文の詳細を見る
A model of the renal medulla in which active NaCl transport was restricted to the thick ascending limb of Henle was investigated. The model contained a vas rectum, a loop of Henle, a collecting duct, interstitium, as functional units, salt and urea as solutes, and the movement of water. The permeability coefficients were mainly estimated from the laboratory data of Drs. Imai and Kokko which were obtained from the per fusion study using isolated tubules of the rabbit kidney. The computation of this model was performed by digital computer. The results reveal that the osmolarity and Na^+ concentration in the renal medulla can rise towards the tip of the papilla without an active Na^+ pump in the ascending thin limb of Henle. It is suggested that the characteristics of Henle's loop for the permeability of solutes and solvent plays an important role to make the concentration gradient in the inner medulla.
北里大学の論文
1976-10-31