血液蛋白に及ぼすZn^<++>の影響 : (第1報)特に"Zn^<++>凝固経路"について
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概要
- 論文の詳細を見る
A small quantity of zinc ions has the effect to induce precipitations in blood serum, and to generate the cryofibrinogen and cryofibrin complexes in blood plasma at a low temperatures. The precipitations induced in blood serum at a low temperatures by the action of zinc ions dissolve again at 37℃. Cryofibrinogen and the cryofibrin appear together in blood plasma at a low temperatures in the presence of zinc ions, and at 37℃, the cryofibrinogen dissolves again, but the cryofibrin does not dissolve further. "Cryofibrin" is a term coined by the author. This appears only at a low temperatures, and after its appearance, does not disappear even at 37℃. The author found the presence of a specific blood coagulation system in which the lower, the temperature, the faster coagulation proceeds. That is, the specific blood coagulation system is more easily activated at a lower temperatures in the presence of zinc ions, in contrast with the intrinsic blood coagulation, system which is more easily activated at a temperatures in the presence of calcium ions. Zinc ions accelerate the former specific system, but arrest the latter intrinsic system. "The lower temperature blood coagulation system" or "Zinc ions pathway of blood coagulation" are the terms the author has given to denote the specific system. The cryofibrinogen and cryofibrin complexes appear in blood plasma at a low temperatures by the activation of the lower temperature blood coagulation system or zinc ions pathway.
- 北里大学の論文
- 1975-08-31