Differences in the Aging-Associated Trends of the Monophasic Action Potential Duration and Effective Refractory Period of the Right and Left Atria of the Rat

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概要

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• Background The incidence of atrial fibrillation (AF) increases with aging, but the aging-associated electrophysiological changes of atrial myocardium are poorly understood. Methods and Results Based on the hypothesis that aging of the atrium enhances AF susceptibility, 30 Wistar rats were divided into 3 age groups: adult, middle-aged, and aged (n=20 per group). Their hearts were isolated and perfused by Langendorff apparatus. Monophasic action potential duration at 90% repolarization (MAPD_<90>) and effective refractory period (ERP) at the basic stimulation cycle length (BCL: 400ms), and MAPD_<90> at other different stimulation cycle lengths in each age group were measured. At the BCL, the MAPD_<90> of the right atrial myocardium was prolonged from the adult to the aged group, that of the left atrial myocardium was prolonged from the adult to middle-aged group, and the MAPD_<90> of the left atrial myocardium in the aged group were shorter than that in the adult and middle-aged groups. The ERP of the atrial myocardium showed the same ageassociated trend as MAPD_<90>. As the stimulation frequency increased, the MAPD_<90> of both the left and right atrial myocardium shortened correspondingly in the adult and middle-aged groups, but in the aged group the MAPD_<90> of the right atrial myocardium shortened markedly more than that of the left atrial myocardium. Conclusions There are different aging-associated electrophysiological changes in the right and left atrium, and the older heart is more vulnerable to developing the substrate for AF.

• 社団法人日本循環器学会の論文
• 2006-02-20

著者

• ZHAO Dongdong

  Department of Cardiology, Renmin Hospital of Wuhan University

• HUANG Congxin

  Department of Cardiology, Renmin Hospital of Wuhan University

• Li Lan

  Geriatrics Renmin Hospital Of Wuhan University

• Huang Congxin

  Department Of Cardiology Renmin Hospital Of Wuhan University

• Zhao Dongdong

  Department Of Cardiology Renmin Hospital Of Wuhan University

• Ding Wenmao

  Department of Cardiology, Renmin Hospital of Wuhan University

• Ding Wenmao

  Department Of Cardiology Renmin Hospital Of Wuhan University

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